Survivorship after cancer and its late effects (SCALA)

Objectif(s) de la recherche et intérêt pour la santé publique

Finalité de l'étude

Objectifs poursuivis

Domaines médicaux investigués

Bénéfices attendus

The population of cancer survivors is rapidly growing owing to improvements in early detection and treatment of cancer. Quality of life, which encompasses physical, psychological and social well-being, is often altered in cancer survivors and remains understudied. The SCALA study aims to identify the major late and long-term consequences of cancer and its treatment amongst cancer survivors, their determinants and their impact on quality of life, overall and by cancer type. The study will be embedded in two existing and prospective large French cohorts (Constances and Gazel) with existing quality of life, social, lifestyle and health data collected at baseline and annually. These cohorts are linked to the SNDS, which has information on cancer diagnosis and treatment. Furthermore, extensive quality of life information will be newly collected in cancer survivors participating in these cohorts using a validated questionnaire. Findings from the SCALA study will provide immediate insights into the late and long-term effects of cancer and its treatment experienced by cancer survivors and their impact on quality of life. The study will also generate evidence to inform tertiary prevention of cancer through lifestyle modification and will help identify cancer survivors at higher risk of developing late and long-term effects who would thus need reinforced surveillance and advice during their post-cancer life-course.